Funtasma Arena 2020 Women's 5TuMR3b8

Funtasma Arena 2020 (Women's) 5TuMR3b8
Funtasma Arena 2020 (Women's)
Figure 2.

Kaplan-Meier curves of survival without hospital readmission for heart failure in trained patients (broken line) and untrained patients (solid line) during follow-up. + indicates censored cases.

Cardiac Deaths

Mortality was significantly lower in trained than in untrained patients (RR=0.37; 95% CI, 0.17 to 0.84; =0.01). All deaths (6 during the training phase and 23 during follow-up) were cardiac in nature (congestive heart failure, myocardial infarction, or arrhythmia), and death occurred more frequently in patients with than in those without ischemic heart disease (24 versus 5 deaths, respectively). Six deaths were sudden. Patients who died had higher resting heart rate, end-diastolic diameter, and wall thickening score index and lower systolic blood pressure and oxygen uptake at peak exercise than patients who survived.

On univariate analysis, the best predictors of improvement in functional capacity were the change in ventilatory threshold and ventilation after training ( r =0.67 and 0.62, respectively; P <0.001 for both). Stepwise forward logistic regression was performed to assess the independent predictors of posttraining changes in peak V̇ o 2 using the univariate variables with higher correlation coefficients. The most significant predictors of posttraining change in peak V̇ o 2 were 201 Tl uptake score index (β-coefficient −0.15; P =0.006) and peak V̇ o 2 at baseline (β-coefficient 1.05; P =0.001). Patients with a 201 Tl uptake score index >2.1 and a peak V̇ o 2 <11.3 mL · kg −1 · min −1 at baseline had the lowest probability of improving their functional capacity (log rank 6.47; P =0.01).

The survival model showed an overall effect of exercise training on predicting all cardiac events (log rank 14.29; P =0.002) (Figure 3 ). A lower event-free survival rate was observed in untrained patients with higher end-systolic diameter ( P =0.008) and ventilation at baseline ( P =0.01) and lower change in fractional shortening after exercise training ( P =0.02). Moreover, there was a significant difference between survival curves when separated by exercise training (log rank 6.24; P =0.01) (Figure 4 SKECHERS Atomic Fiery soatPo
). Patients with thallium uptake score <2 at baseline had a significantly lower mortality rate (log rank 15.08; P <0.001) and a lower incidence of overall cardiac events (log rank 9.56; P =0.002). However, the trend of survival curves was similar when patients were separated by age, cause of heart failure, number of diseased vessels, and number of prior myocardial infarctions. Analysis by Cox proportional hazards model with cardiac death as the dependent variable showed that ventilatory threshold at baseline and thallium uptake score index after training were the only independent predictors (β-coefficients 0.378 and −0.165, P =0.0004 and 0.008, respectively).

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An arm type in which a group of participants receives the intervention/treatment that is the focus of the clinical trial.
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A type of eligibility criteria . These are the reasons that a person is allowed to participate in a clinical study.
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For more information, see Participating in Studies on this site.

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An arm type in which a group of participants does not receive any intervention/treatment during the clinical trial.
A type of clinical study in which participants are identified as belonging to study groups and are assessed for biomedical or health outcomes. Participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to a specific interventions/treatment .
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A type of intervention model describing a clinical trial in which two or more groups of participants receive different interventions. For example, a two-arm parallel assignment involves two groups of participants. One group receives drug A, and the other group receives drug B. So during the trial, participants in one group receive drug A "in parallel" to participants in the other group, who receive drug B.
A summary of the progress of participants through each stage of a clinical study, by study arm or group/cohort . This includes the number of participants who started, completed, and dropped out of the study.
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA) . The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0) , Phase 1 , Phase 2 , Phase 3 , and Phase 4 . Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
A phase of research to describe clinical trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal is to determine the drug's most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These trials usually involve a small number of participants.
A phase of research to describe clinical trials that gather preliminary data on whether a drug works in people who have a certain condition/disease (that is, the drug's effectiveness). For example, participants receiving the drug may be compared to similar participants receiving a different treatment, usually an inactive substance (called a placebo ) or a different drug. Safety continues to be evaluated, and short-term adverse events are studied.
A phase of research to describe clinical trials that gather more information about a drug's safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. These studies typically involve more participants.
A phase of research to describe clinical trials occurring after FDA has approved a drug for marketing. They include postmarket requirement and commitment studies that are required of or agreed to by the study sponsor. These trials gather additional information about a drug's safety, efficacy, or optimal use.
Describes trials without FDA-defined phases , including trials of devices or behavioral interventions.
An inactive substance or treatment that looks the same as, and is given in the same way as, an active drug or intervention/treatment being studied.
An arm type in which a group of participants receives a placebo during a clinical trial.
The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure . Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "estimated" primary completion date is the date that the researchers think will be the primary completion date for the study.
In a clinical study's protocol , the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment . Most clinical studies have one primary outcome measure, but some have more than one.
The main reason for the clinical trial . The types of primary purpose are: treatment, prevention, diagnostic, supportive care, screening, health services research, basic science, and other.
The person who is responsible for the scientific and technical direction of the entire clinical study.
The written description of a clinical study. It includes the study's objectives, design, and methods. It may also include relevant scientific background and statistical information.
National Library of Medicine (NLM) staff perform a limited review of submitted study records for apparent errors, deficiencies, or inconsistencies. NLM staff identify potential major and advisory issues and provide comments directly to the study sponsor or investigator. Major issues identified in QC review must be addressed or corrected (see First submitted that met QC criteria and Results first submitted that met QC criteria ). Advisory issues are suggestions to help improve the clarity of the record. NLM staff do not verify the scientific validity or relevance of the submitted information. The study sponsor or investigator is responsible for ensuring that the studies follow all applicable laws and regulations.
A type of allocation strategy in which participants are assigned to the arms of a clinical trial by chance.
Not yet recruiting:
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Citizens' Climate Lobby > CCL News > Honoring a friend by supporting CCL
Posted on June 29, 2018 in CCL News

Bill Betchart (second from left) lobbies Rep. Anna Eshoo in November 2017 with a team of fellow CCL volunteers.

By Tim Dec

As many of you know, CCL puts high value on relationship. By relationship, I mean with our members of Congress, with editorial boards, with other partner groups, and even with those who might not agree with us. But for me, the most important relationships have been with other CCLers. It’s these relationships where I draw inspiration and support in this often challenging work.

I joined CCL when the Silicon Valley North chapter was founded almost five years ago along with a group of others, one of which was Bill Betchart. Tasha Reddy, who went on to become a co-lead of the chapter and is now CCL’s California state coordinator, invited Bill and me to an upcoming group start training. I did not know Bill at the time, but from that point on, both Bill and I were hooked on CCL.

Remembering Bill Betchart

Professionally, Bill was a water resources engineer most recently working in the Sacramento delta area of California. Bill’s wife, Margaret, was the owner of Betchart Expeditions , which specializes in natural history expeditions where Bill was “one of Margaret’s right hands.” Between his professional work and his work and travels with Betchart Expeditions, he saw firsthand the challenges and impacts of a changing climate.

Without exception, Bill attended every chapter meeting, every CCL social event, and even helped with some major donor fundraising. So, Bill was always there and was a core member of our Silicon Valley North family. Though focused and diligent in his work with CCL, he was always up for some fun as shown in this photo at one of our early chapter socials.

Bill was a passionate supporter of CCL’s policy and approach, and he was a tireless liaison to our member of Congress, Lucky Brand Ariah Sp1k6
. I was Bill’s roommate for all our June Lobby Day conferences, and Bill became a very dear friend. Bill so believed in the mission of CCL that he stayed involved and engaged even as he was fighting cancer—to the very end. He lost that fight in February of last year. Soon after his passing and as a result of his diligence and persistence, Rep. Anna Eshoo joined the bipartisan House Climate Solutions Caucus .

Honoring Bill with donations in his name

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